“In future this delivery will be a leading way to deliver therapeutic agents due to its some unique characters…”
-Rajput et al., International Journal of Research in Pharmaceutical and Biomedical Sciences. 2012; 3(1): 118
When sending a parcel, one must choose the proper delivery method. First-class delivery is best for small, urgent items, priority is best for perishable items and standard post is best for everything else. When administering drugs, one must also choose the proper delivery method. Pulse-release drug delivery systems are useful for certain conditions, such as chronopharmacological diseases, biological tolerance and gastric environment.
Pulse-release drug delivery aids treatment of chronopharmacological diseases. Chronopharmacological diseases are diseases affected by circadian rhythms. For example, blood levels of hormones, such as cortisol, fluctuate throughout the day, and asthma attacks and rheumatoid arthritis flare ups are more common in the morning. Such diseases benefit from a drug delivery system that releases a pulse of medication in the early hours of the morning, before the attack or flare up is most likely to occur.
Biological tolerance is another condition for which pulse-release drug delivery systems are used. Biological drug tolerance is the reduced efficacy of a drug due to prolonged exposure. Antibiotics are an example of drugs to which patients build up a tolerance. Because a pulse-release drug delivery system releases medication at necessary intervals instead of at a constant pace, it reduces the likelihood that the medication will lose its efficacy. This has been proved through experiments with amoxicillin.
Pulse-release drug delivery systems help combat harsh gastric environments. Elements of the gastric environment may cause chemical instability if a drug is exposed for a prolonged time. In such cases, a continuous-release system is inferior to a pulse-release delivery system. Additionally, if medication needs to reach the colon, it is vital that drug release is prevented in the upper gastrointestinal tract. Therefore, a pulse-release drug delivery system is more efficacious because it releases the drug only in the colon and not in the first two-thirds of the gastrointestinal tract.
Chronopharmacological diseases, biological tolerance and gastric environment are conditions that use pulse-release drug delivery systems. Two fields in which we at Orbis Biosciences expect to see pulse-release use grow are ocular delivery and vaccines.
Just as one must choose the best delivery method when sending a parcel, one must also choose the best delivery method for drug administration. That choice becomes easier with the availability of pulse-release drug delivery systems.