“The size of particles is directly linked to their potential for causing health problems. Small particles less than 10 micrometers in diameter pose the greatest problems, because they can get deep into your lungs, and some may even get into your bloodstream.”
– United States Environmental Protection Agency, Particulate Matter. Health.
“Take a deep breath” is sometimes said in times of stress. However, taking a deep breath could be dangerous for physicians and caregivers exposed to multiparticulate drug fines. The inhalation of drug fines can not only cause irritation and work-disrupting symptoms but also pose real danger to one’s health. The inhalation of medication fines can affect lung function, affect a pregnancy and disrupt systemic vascular function.
The inhalation of fines can affect lung function, worsening asthma and heart conditions. The New York State Department of Health defines fine particulate matter as particles in the air that are 2.5 microns in width or smaller (PM2.5). It writes,
“Scientific studies have linked increases in daily PM2.5 exposure with increased respiratory and cardiovascular hospital admissions, emergency department visits and deaths. Studies also suggest that long term exposure to fine particulate matter may be associated with increased rates of chronic bronchitis, reduced lung function and increased mortality from lung cancer and heart disease. People with breathing and heart problems, children and the elderly may be particularly sensitive to PM2.5.”
Inhaling fines can also affect pregnancy. A 2014 study in Toxicology Letters found that the inhalation of fines during pregnancy increased levels of IL-4 cytokine in the fetal portion of the placenta. The authors write, “Increased IL-4 suggests that a placental inﬂammatory reaction may have occurred in response to exposure to ﬁne particulate matter and that this cytokine was responsible, among possibly others factors, for resolution of the inﬂammatory reaction.”
The inhalation of fines can disrupt systemic vascular function, as well. A 2007 study in Inhalation Toxicology found that inhalation of fines with an aerodynamic diameter between 0.02 and 1 microns during high exercise impaired flow-mediated brachial artery dilation and reduced muscle reperfusion.
Inhaling fines can affect lung function, affect a pregnancy and disrupt systemic vascular function. Orbis Biosciences® uses Precision Particle FabricationTM technology to create medication without fines. This optimized manufacturing approach creates uniform microparticulates in a single-step process. This eliminates fines and the adverse effects they can have on physicians and caregivers.